EPHA2 and cortical cataract: Jun et al. [35] had observed that EphA2 knockout mice developed using either a secretory gene trapping strategy of partial EphA2 ectodomain fused to β-gal on FVB/NJ genetic background [134,135] or a retroviral insertion into the first intron of EphA2 gene on C57BL/6 genetic background [136] developed age-related cortical cataracts.