PITX3 and Parkinson disease: More recently, de Mena et al., searching for DNA variants in miR-133 and PITX3 genes in PD patients (n = 777) and healthy controls (n = 650) from Spain, suggested that miR-133 and PITX3 gene variants did not contribute to the risk for PD, thus contrasting these data, at least in those specimens [67].