We therefore assessed whether gmr-Gal4-driven expression of cisd2 RNAi modified the phenotypes in several genetic models of neurodegeneration (autosomal dominant retinitis pigmentosa, ataxia telangiectasia, Parkinson disease, Alzheimer disease, etc., supplementary material Table S3). This evidence concerns the gene CISD2 and early-onset autosomal dominant Alzheimer disease.