PROM1 and Blindness: This assumption is further strengthened by recent results showing that PROM1 can substitute the Drosophila protein in prom mutant fly PRCs and that expression of PROM1, which carries a mutation that has been associated with the development of blindness (hProm1R373C), results in morphologically defective rhabdomeres when expressed in fly PRCs (Nie et al., 2012).