In humans, variation in this repeat results in variable expression of the MMP3 gene, associated with risk of heart disease: the 5T allele results in higher MMP3 expression and is associated with myocardial infarction and aneurysm, whereas the 6T allele drives a lower MMP3 expression and is associated with coronary artery disease [50]. The gene discussed is MMP3; the disease is myocardial infarction.