The prevailing influence of EWS/FLI in Ewing sarcoma provides a unique opportunity to further characterize the oncogenic properties of EWS/ETS proteins, with hope that this growing body of knowledge will allow for a greater understanding of the molecular basis of oncogenesis and facilitate the development of more targeted, clinically efficacious therapy for this devastating malignancy. Here, EWSR1 is linked to Ewing sarcoma.