PTK2 and neoplasm: Focal adhesion kinase (FAK) carries out protein–protein interaction adaptor functions at sites of cell attachment to the ECM, contributing to focal-adhesion “scaffolding”, and also transmits adhesion-dependent signals into the cell interior.12 Several studies have indicated that FAK has a direct role in tumor growth and survival by activating survival pathways of PI3K/AKT and MAPK/ERK.13,14