The repression of Miz1 target genes by Miz1/c-Myc and by Miz1/BCL6 complexes is important in physiological apoptotic responses [35] and in B-cell development [48] respectively; however, the inappropriate repression of cell-cycle inhibitors contributes to deregulated proliferation in tumours associated with the overexpression of c-Myc [51,52] or BCL6 [48]. The gene discussed is BCL6; the disease is neoplasm.