SLC7A11 and Kaposi's sarcoma: We note, for example, that in KSHV/HIV coinfected individuals who are generally at a greater risk of developing the most aggressive form of KS, HIV serves as a cofactor for KS not only through establishment of an immunosuppressed environment but also through upregulation of the KSHV receptor, xCT [82], to facilitate KSHV dissemination.