The early stage is also associated with secretion of protumorigenic mediators such as vascular endothelial growth factor (VEGF) that drives the angiogenic increase in hyperproliferating spindle cells, which in turn form the basic slit-like framework for erythrocyte extravasation, neovascularization, and plasma cell infiltration; together, these biologic processes are believed to contribute to the complex cellularity found in KS lesions [6, 7, 10–14]. The gene discussed is VEGFA; the disease is Kaposi's sarcoma.