ETS1 and systemic lupus erythematosus: For the other polymorphism in our study, the rs57095329 A/G SNP in the miR-146a promoter region, it has also been shown to reduce the level of mature miR-146a by decreasing the binding of its transcription factor V-Ets oncogene homolog 1 (Ets-1) and was associated with the risk of developing systemic lupus erythematosus (SLE) [22].