With regards to the rs57095329 polymorphism, Luo et al. reported that this polymorphism was located in the promoter of miR-146a and the risk-linked G allele reduced the protein-binding affinity of the transcription factor Ets-1, thus, resulting in decreased levels of miR-146a in patients with SLE [22]. This evidence concerns the gene ETS1 and systemic lupus erythematosus.