The levels of the tumor initiators HER2 and KRAS and metastasis genes VEGF, CXCL-4, CCL5, NEDD9 and RHoC were reduced in MCF-7 cells with UBE2C knockdown (Figure 5A) and increased with UBE2C overexpression (Figure 5B). This evidence concerns the gene RHOC and neoplasm.