In summary, in this well-characterized cohort of Brazilian patients with HIV/AIDS with long-term exposure to cART, an age over 50 years, a current CD4 count less than 350 cells/mm3, diabetes, hypertension, previous use of tenofovir, and previous use of indinavir were associated with a decreased glomerular filtration rate (p<0.05). This evidence concerns the gene CD4 and hypertensive disorder.