As a key regulator of inflammation, it is not surprising that MIR146A variation has also been implicated in oncogenesis and vascular endothelial activation, as well as other inflammatory and autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis and systemic lupus erythematosus (SLE) [52], [56]–[59]. This evidence concerns the gene MIR146A and systemic lupus erythematosus.