As a key regulator of inflammation, it is not surprising that MIR146A variation has also been implicated in oncogenesis and vascular endothelial activation, as well as other inflammatory and autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis and systemic lupus erythematosus (SLE) [52], [56]–[59]. The gene discussed is MIR146A; the disease is autoimmune disease.