As a key regulator of inflammation, it is not surprising that MIR146A variation has also been implicated in oncogenesis and vascular endothelial activation, as well as other inflammatory and autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis and systemic lupus erythematosus (SLE) [52], [56]–[59]. Here, MIR146A is linked to rheumatoid arthritis.