However, one remarkable exception was the AKT inhibitor VIII, for which the presence of DERL3 promoter CpG island hypermethylation was significantly associated with enhanced sensitivity in the panel of 22 colorectal cancer cell lines (multivariate analysis of variance test, FDR<0.01, P=0.003) (Fig. 5d). The gene discussed is AKT1; the disease is colorectal cancer.