Most importantly, as we also noted in the HCT-116 colon cancer cell line model, we observed that the presence of DERL3 CpG island hypermethylation in primary colorectal tumours was associated with overexpression of the SLC2A1 protein determined by immunohistochemistry (Fisher’s exact test, P=0.05, n=16) (Fig. 6b). This evidence concerns the gene DERL3 and malignant colon neoplasm.