DERL3 and colorectal cancer: Comparing the DERL3 methylation data against the clinicopathological values of colorectal cancer patients, for 81 cases for which this information was available, we found that DERL3 CpG island hypermethylation was associated with shorter relapse-free survival (Kaplan–Meier analysis, log rank, P=0.016; hazard ratio 3.58; 95% CI: 1.27–10.07) (Fig. 6d).