Most importantly, the CpG island hypermethylation of DERL3 was not restricted to the cultured cells of these other tumour types, because the DNA methylation microarray approach applied to 1,186 human primary malignancies corresponding to the 14 tissue types revealed that DERL3 CpG island hypermethylation was also commonly found in similar tumour types than those of the cancer cell lines (Fig. 6e and Supplementary Table 3). Here, DERL3 is linked to neoplasm.