An examination of the mechanism underlying P-407-induced hyperlipidemia demonstrated marked alterations in the activities of plasma hepatic lipase (EC 3.1.1.3) and lipoprotein lipase(EC 3.1.1.34), which belong to members of the α/β hydrolase fold family similar to CES (EC 3.1.1.1) [35]. Here, LIPC is linked to hyperlipidemia.