In our study, because we observed the significant association of CD44 SNP rs187115 functional variant G with oral cancer susceptibility in stage III and IV OSCC patients, and CD44 SNP rs187115 was observed to be associated with chemoresistance [20], we proposed that the oral CSC characteristics of CD44 contributed to the chemoresistance of the rs187115 polymorphism in oral cancer, and the CD44 SNP rs187115 polymorphism might act as a marker to predict poor prognosis in OSCC patients. This evidence concerns the gene CD44 and lip and oral cavity carcinoma.