The correlation between elevated systemic levels of TNF-α and dengue disease severity has been reported in a number of in vivo mouse model of severe dengue [24], [25], [35], [36], [37], [46], [54], [61], among which four of them have used anti-TNFα antibody treatment to demonstrate a reduced mortality rate [25], [37], [46], [61]. The gene discussed is TNF; the disease is dengue disease.