IL22 and infection: IL-22 was elevated in brains of mice with pneumococcal meningitis as compared with uninfected controls at 24 h after infection (uninfected controls vs. infected wild type mice: 1.82±0.29 pg/mg brain protein vs. 4.08±1.51 pg/mg brain protein, p<0.001) and 48 h after infection (uninfected controls vs. infected wild type mice: 1.37±0.19 pg/mg brain protein vs. 3.15±1.78 pg/mg brain protein, p = 0.012).