CCR6 and pneumococcal meningitis: As the infiltration of the subarachnoid space is dominated by neutrophils during pneumococcal meningitis, we next evaluated direct effects of CCL20 on neutrophil recruitment in vitro and in vivo. Finally, the findings were validated and explored in a well-established animal model of pneumococcal meningitis by blocking CCL20 pharmacologically and by the evaluation of CCR6-deficient mice.