Angiotensin II type 1 (AT1) receptor, belonging to the G-protein-coupled receptor family (GPCRs), shares a common structure of 7-transmembrane receptor (7TMRs), and mediates the signal response of Angiotensin II (AngII), thereby regulates blood pressure, cardiac hypertrophy and heart failure [1], [2]. The gene discussed is AGT; the disease is heart failure.