We have previously showed that some kinds of angiotensin II receptor blockers (ARBs), such as candesartan and olmesartan, inhibit pressure overload-induced cardiac hypertrophy in angiotensinogen knockout (AGT KO) mice, while others like valsartan, exert the inhibitory effect in the presence of AngII [6]. The gene discussed is AGT; the disease is cardiac hypertrophy.