The combined analysis in up to 26,037 non-diabetic individuals provided genome-wide significant association (p<5×10−8) with insulin secretion measured as corrected insulin response (CIR) to glucose at 30 min during an OGTT for the locus within the GRB10 gene (lead SNP rs933360 located in intron 2) (Figure 1A, B), and at 7 previously reported T2D and glycemic trait variants, including MTNR1B, HHEX/IDE/KIF11, CDKAL1, GIPR/QPCTL, C2CD4A (NLF1), GCK and ANK1 (Table 1, Table S2A, Figure S1, S2). The gene discussed is INS; the disease is type 2 diabetes mellitus.