VDR and osteoarthritis: Similarly, the VDR-TaqI T allele has been linked with increased risk for osteoarthritis of the knee [82], with concomitant work showing the BsmI–ApaI–TaqI haplotype bAT is associated with reduced risk for osteoarthritis [83] and additionally, that the Bat and BAt haplotypes are significantly associated with osteoporosis [84, 85].