These genes included several previously identified in relation to Rett, autism or ID, such as CRH (MIM*122560; Corticotropin-releasing hormone; dysregulated CRH expression shown in Mecp2 knockout mice; [33], [46]), PTCHD1 (MIM*300828; disruptions may result in autism or ID; [47], [48]), GRIN2A (MIM*138253; a component of synaptic glutamate receptors; mutations have been associated with seizures and ID, [49]), DLGAP2 (MIM*605438; CNVs disrupting this gene have been identified in autism; [50]). This evidence concerns the gene MECP2 and autism.