MAPK3 and Yersinia infectious disease: We thus calculated the MIS (Minimum Intervention Set [6], see methods section) for IL-10 production by assigning the MIS goal to be ERK1.2 = 0, while keeping MKK6, IKK, TRAF6 and TRAF3 = 0 such that the effect of Yersinia infection is considered as starting condition in the model.