Further fine-mapping analysis of IL genes or high-density whole genome genetic analyses evaluating different CAD phenotypes might give further insights to the pathophysiologic mechanisms underlying LMCAD; Third, a single case–case study is not sufficient to fully interpret the relationship between IL-6R rs7529229 T/C polymorphism and susceptibility to LMCAD because of the relatively small number of patients with LMCAD. Here, IL6R is linked to coronary artery disorder.