Along with Th2-skewed cytokines, HNSCC tumors secrete increased levels of immunosuppressive factors such as TGF-β that function to directly inhibit cytotoxic T cell-mediated immunity and recruit immunosuppressive cells, including myeloid-derived suppressor cells (MDSCs) and M2-skewed macrophages, to the tumor site [19,20]. The gene discussed is TGFB1; the disease is neoplasm.