IRF8 and systemic lupus erythematosus: Among European identified SLE loci were HLA loci HLA-DRA [5] and ATG5 [5], immune signal transduction loci BANK1 [6], BLK [5], LYN [5], TLR, and IFN pathway related loci IFIH1 [7], STAT4 [8], TNFAIP3 [9], IRF7 [5], IRF8 [7], as well as NCF2 [7], IL10 [10], PHRF1 [5], CD44 [11], ICAM1_ICAM4 [7], TYK2 [7], and UBE2L3 [5].