In CH published non-HLA loci SNPs showed significant association with SLE (Supplementary Table 3), including ETS1 (rs1128334, PCH = 2.4 × 10−3), IRF8 (rs2280381, PCH = 1.38 × 10−2), TNFAIP3 (rs5029939, PCH = 1.62 × 10−2), STAT4 (rs3821236, PCH = 1.86 × 10−2), and RASGRP3 (rs13385731, PCH = 3.63 × 10−2). This evidence concerns the gene IRF8 and systemic lupus erythematosus.