Functional adenomas mainly include GH-secreting adenomas (GHomas),TSH-secreting adenomas (TSHoams), prolactinsecreting adenomas (PRLomas), ACTH-secretingadenomas (ACTHomas), LH-secreting adenomas(LHomas) and FSH-secreting adenomas (FSHo-mas). This evidence concerns the gene PLOD1 and prolactin-producing pituitary gland adenoma.