For example, the association of HS6ST1,HS6ST2, MATER and CHM genes with POF wereidentified following to the analysis of the POF patients with karyotypes 46, X, der (X) t (X; 19) (p21;q13), 46, X, t (X; 2) (q21; q14), 46, X, der (X)t (X;Y) (q25-26; q11.22), 46, X, t (X; 4) (q21.2; p16.3)respectively (31, 32). This evidence concerns the gene CHM and premature menopause.