FLT3 and acute myeloid leukemia: However, our results are slightly lower than many studies on the frequency of FLT3-TKD in AML (Table 3) which were performed by Abu-Duhier et al. [27], Yamamoto et al. [28], Thiede et al. [22], Moreno et al. [26], and Fröhling et al. [8]; according to these studies, FLT3-TKD mutation shows an incidence of 5.8% to 7.7% in AML.