Similarly, the rate of FLT3-TKD mutation (D835) in our study is 4.12% (4/97) which is less frequent than FLT3-ITD mutation (14/97), these results are in accordance with the published studies on the frequency of FLT3-TKD in AML performed by many study groups [20, 22, 27, 28]; the rate of FLT3-TKD mutation (D835) in our study is almost very close to the largest study done by Bacher et al. [23] in which FLT3-TKD mutations were detected in 147 of 3082 (4.8%) patients. This evidence concerns the gene FLT3 and acute myeloid leukemia.