CXCR4 and psoriasis: Importantly, in the present study, we found that both CXCR4 and SDF-1 were also upregulated in two independent experimental mouse models of chronic, psoriasis-like skin inflammation, namely the chronic skin inflammation induced in K14-VEGF-A transgenic mice [9], [10] and the cutaneous inflammation induced by topical treatment of mouse skin with imiquimod [24], [25].