TNFRSF10A and sexually transmitted disease: In this study, we investigate the effect of TRAIL-R1 SNPs in regulating susceptibility to C. trachomatis infection among women from a population at risk for STDs, identify TRAIL-R1 as a downregulator of inflammation in human cells, and elucidate the role of murine TRAIL-R in the inflammatory response against chlamydial infection in vitro.