Recent investigations have demonstrated that transport of melanin-concentrating hormone receptor 1 (MCHR1) and SST3 to cilia is compromised in Bbs2-/- and Bbs4-/- mice [13] and that impaired BBSome assembly contributes to the etiology of BBS phenotypes associated with the loss of function of BBS6, BBS10 and BBS12 genes [14]. Here, MCHR1 is linked to Bardet-Biedl syndrome.