These findings, considered with the differential concentration of ciliopathy in areas of Bbs4-/- brain that mediate cognition and learning (the other areas to be investigated), provide a strong rationale for a more detailed functional analysis of the role of cilia in neuronal communication as well as the role that ciliopathy may play in the genesis of the symptoms characteristic of BBS. This evidence concerns the gene BBS4 and Bardet-Biedl syndrome.