In order to investigate potential association between genetic polymorphisms in the Wnt pathway with TB risk, we genotyped three single nucleotide polymorphisms (SNPs) from key genes within Wnt signaling pathway (i.e. rs4135385 in CTNNB1 gene, rs7832767 in SFRP1 gene, rs11079571 in AXIN2 gene) in a case-control study (422 tuberculosis patients and 402 healthy controls) in Chinese Han population. This evidence concerns the gene CTNNB1 and tuberculosis.