In the present study we will examine factors related to donor (age, liver steatosis), pre-transplant recipient (age, sex, HCV viral load, coinfections, SNPs of OAS gene, IL1β and IL-28β gene and posttransplant recipient immunosuppressive drugs, i.e., cyclosporine (CS), FK, and mycophenolate mofetil (MMF)), and their association with HCV recurrence following liver transplantation. This evidence concerns the gene SMOC1 and fatty liver disease.