Prostate cancer (PC) is second in incidence among malignancies in men in Western countries [1]; the treatment of clinical localized disease is radical prostatectomy (RP) in many cases, and the decrease of the serum total prostate-specific antigen (PSAt) values below 0.1-0.2 ng/mL within 1 month after surgery documents complete tumour eradication [2]. This evidence concerns the gene KLK3 and pachyonychia congenita.