Figure 3A demonstrates that diabetes increases SOCS3 levels, which is blocked in diabetic animals receiving the intravitreal injection of IGFBP-3 NB. Accordingly, IRTyr960 phosphorylation is reduced in IGFBP-3 NB treated animals compared to untreated diabetic rats (Figure 3B). IGFBP-3 NB injection significantly decreased SOCS3 and IRTyr960 when compared to injection of empty vector. The gene discussed is IGFBP3; the disease is diabetes mellitus.