In patients with CIS, Q KFLC showed a significant correlation with CSF leukocyte count (p<0.001, R = 0.46), CSF CXCL13 levels (p<0.001, R = 0.64) and also intrathecal IgG synthesis (p<0.001, R = 0.74). This evidence concerns the gene CXCL13 and in situ carcinoma.