CDKAL1 and type 2 diabetes mellitus: However, the SNPs within the T2DM associated gene CDKAL1, rs9356744 and rs2206734, were observed to be associated with HOMA-IR (β = 0.02, adjusted p = 0.042 and β = 0.025, adjusted p = 0.025, respectively) in linear regression models co-varied for body mass, age, gender and pubertal development (Table 2).