A candidate gene for epigenetic regulation of lymphomagenesis is Tissue Factor Pathway Inhibitor-2 (TFPI-2), a Kunitz-type serine proteinase inhibitor that directly regulates the activation of matrix metallo-proteinases (MMPs) and plays a significant role in the regulation of ECM degradation, which is an essential step for cell remodeling, as well as tumor invasiveness and metastasis. Here, TFPI2 is linked to neoplasm.