HPGD and colorectal carcinoma: The rs1346271 and rs1426945 SNPs in HPGD gene were associated with a 32% and 44% decreased risk for CRC onset (95%CI:0.47–0.96, P = 0.029 and 95%CI:0.34–0.93, P = 0.026, for the GC and AA homozygous carriers of the rs1346271 and rs1426945 polymorphisms, respectively).