The COX-2 gene is genetically polymorphic and was the target of several genetic association studies, implicating the involvement of three polymorphism in COX-2 gene on colorectal tumors development (rs20417, rs699466 and rs5275, also known as −765G>C, −1195A>G and 8473T>C, respectively), although not always consistently [18]. Here, PTGS2 is linked to colorectal neoplasm.