TLR3 and herpes simplex encephalitis: We have demonstrated that the HGC is an effective approach for identifyingMendelian disease-causing genes in high-throughput genetic data, by the ranking ofgenes according to their biological proximity to core genes known to be associatedwith the phenotype of interest, as demonstrated by a case study of herpes simplexencephalitis (HSE) and TLR3 pathway genes [10].