Since we found that levels of RIG-1 expression are elevated in the temporal cortex from MCI patients when compared to end-stage AD pathology (AD, Figures 1 and2), we stimulated human cortical astrocytes with 3-42 Aβ for 18 hours at different concentrations (C, 0.5, 1 and 3 μM) to determine if Aβ peptide levels regulate the protein expression levels of RIG-1. This evidence concerns the gene RIGI and Alzheimer disease.