Stimulation of RIG-1 with 4 μg/ml 5′ppp dsRNA, which activates RIG-1 signaling in astrocytes, resulted in a significant elevation in the expression of APP and Aβ when compared to the control group, suggesting an involvement of RIG-1 signaling in the expression of two hallmark proteins in AD pathology. Here, RIGI is linked to Alzheimer disease.