APP and Alzheimer disease: During the last years, intraneuronal accumulation has been reported in several mouse models including APPSDLPS1M146L[41], APPSLPS1M146L[42], Tg2576[43], 3xTg-AD[19], APPArc[44,45], 5XFAD[21], APPT714I[46], APPSL/PS1M146L[47], APP/PS1KI[20,48,49], TBA2 mice expressing pyroglutamate modified Aβ3–42[50] and in Tg4-42 expressing Aβ4–42[23].