CHRM1 and adenocarcinoma: In contrast, more than 50% of WT, Chrm1-/- and dual KO mice had multiple (two to seven) adenocarcinomas per section and only two of 20 WT (10%) and one of 12 dual KO (8%) mice had no adenocarcinomas (P < 0.01 for reduced multiplicity of tumors in colons from Chrm3-/- mice vs. colons from the other three genotypes).