As shown in Figure 5, phosphorylation of Btk and PLCγ2 was similarly inhibited by ibrutinib in both sensitive cell line SU-DHL-16 and not-sensitive cell line OCI-Ly7, which suggested that ibrutinib induced the anti-lymphoma effect on GCB-DLBCL cell lines through the inhibition of BCR signal pathway. The gene discussed is BCR; the disease is diffuse large B-cell lymphoma.