Although it is reported that the survival of GCB-DLBCL did not so much rely on activated NF-κB pathway [27], in our investigation we indeed found that the viability of some GCB-DLBCL cell lines was also inhibited by ibrutinib and different GCB-DLBCL cell lines showed diverse sensitivity. This evidence concerns the gene NFKB1 and diffuse large B-cell lymphoma.