PTK2 and neoplasm: Interestingly, in a study investigating the relationship between FAK and major signaling pathways in 162 node-negative breast cancers, elevated FAK expression correlated with Her2 over-expression and phospho-Src Tyr-215, prompting the authors to speculate that the activation of Akt via the FAK pathway contributes to the aggressive nature of Her2 over-expressing tumours [12].