A weak correlation was found between u-PA and PAI-1 (rs = 0.30, P < 0.023) in conditioned media with aortic stenosis valves (Figure 2(a)), however, an important correlation was found between t-PA and PAI-1 in the same samples (rs = 0.60, P < 0.0001) (Figure 2(b)). The gene discussed is SERPINE1; the disease is aortic stenosis.