Besides its role in the fibrinolytic system, PAI-1 or serpin E1 plays a role in many human vascular disorders, and recent studies revealed that another serpin, serpin E2 also known as protease nexin-1 (PN-1) phylogenetically relative to PAI-1, is produced by most vascular and blood cells [35]. This evidence concerns the gene SERPINE1 and vascular disorder.