In our study, we found that high level of ammonia, which maybe contributed to insufficient detoxification by the liver and muscle and the decrease in urinary loss of ammonia due to alkalosis [13–16], is associated with high levels of IL-1β, IL-6, TNF-α, heme oxygenase-1 gene expression, iNOS gene expression, and nitrite/nitrate. Here, HMOX1 is linked to Alkalosis.