We found also that dexamethasone significantly reduced the heme-oxygenase-1 gene expression, iNOS gene expression, nitrite/nitrate, and the proinflammatory cytokines [IL-1β, IL-6, and TNF-α] and increased IL-10 associated with acute liver injury, with no significant differences in comparison to minocycline. The gene discussed is NOS2; the disease is injury.