RYR2 and diabetes mellitus: Taken into consideration all present and also previously published data, in here, we report that an enhancement of antioxidant defence in diabetics, directly targeting heart, seems to prevent diastolic dysfunction, being associated with normalization of RyR2 macromolecular-complex, and thereby prevention of both Zn2+ and Ca2+ leaks leading to normalization of basal levels of intracellular free Ca2+ and Zn2+ in the heart.