Notably, in here, we have shown that exogenously applied Zn2+ caused marked phosphorylation in RyR2 while there was no effect on the protein levels of both RyR2 and an accessory protein of RyR2 macromolecular complex, FKBP12.6, as well as higher phosphorphorylations in both PKA and CaMKII in a concentration-dependent manner, similar to hyperglycemia. Here, RYR2 is linked to Hyperglycemia.