Although, the mechanism might be down-regulation of lymphocyte-specific protein tyrosine kinase (LCK) gene involved in intrahepatic T-cell signaling in HIV/HCV coinfection (18), which should be further confirmed in the patients., The patients should be followed up to see the effect of GBV-C on chronic hepatitis C-related liver function in patients with HIV/HCV coinfection to further verify the outcome accurately. This evidence concerns the gene LCK and coinfection.